Christelle Huguet

Head of Internal Research

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Christelle Huguet, Ph.D., Head of Internal Research Alexion Pharmaceuticals, focusing on the discovery and development of transformative medicines for patients suffering from rare and devastating diseases.
Before Alexion, Dr .Huguet was Senior Vice President and Chief Scientific Officer of the Inflammation & Remodeling Research Unit at Pfizer Inc, focusing on developing medicines for chronic inflammatory diseases, with an emphasis on chronic pulmonary diseases and chronic kidney diseases. Her research unit investigated the interplay of innate immunity, tissue inflammation and the fibrosis/remodeling processes in the initiation, maintenance and progression of chronic inflammatory conditions.
Prior to this role, Dr. Huguet served in a number of leadership positions within Pfizer Inc, including Chief Scientific Officer of Worldwide Pharmacokinetics Dynamics & Metabolism.
Previously, while working for Pfizer Ltd in Sandwich, U.K., Dr. Huguet held the position of Research Head of the Genito Urinary Therapeutic Area, leading the research strategy covering sexual health, endometriosis, overactive bladder, incontinence, interstitial cystitis and chronic kidney diseases.
Dr. Huguet also further developed Pfizer’s allergy and respiratory biology capabilities, bringing forward novel targets and exploring new mechanisms. There, she served as the Allergy & Respiratory Biology Line Director, where she directed and led the delivery of nine novel compounds. These projects evaluated targets for chronic obstructive pulmonary disease (COPD), asthma, and allergic rhinitis, and included both small molecule and antibody modalities administered by oral, inhaled or injectable routes.
Dr. Huguet studied in France, Germany and Switzerland, receiving a French University Diplomas in Technology (DUT) in applied biology and biochemistry, and a European engineering degree in biotechnology sciences. She received a Ph.D. in molecular and cellular biology from the Institute Pasteur in France.